Gli2 Facilitates Tumor Immune Evasion and Immunotherapeutic Resistance by Coordinating Wnt Ligand and Prostaglandin Signaling [Cell_Line_RNAseq]
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 3 × NTC vs 3 × Gli2CA vs 3 × Cas9-NTC vs 3 × Cas9-Gli2KOGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- GLI2 Facilitates Tumor Immune Evasion and Immunotherapeutic Resistance by Coordinating WNT and Prostaglandin SignalingCancer research · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE279935_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1175576 and SRA study SRP539851. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 4 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8583572 NTC__01 NTC
- GSM8583573 NTC__02 NTC
- GSM8583574 NTC__03 NTC
- GSM8583575 Gli2CA_01 Gli2CA
- GSM8583576 Gli2CA_02 Gli2CA
- GSM8583577 Gli2CA_03 Gli2CA
- GSM8583578 Cas9-NTC1 Cas9-NTC
- GSM8583579 Cas9-NTC2 Cas9-NTC
- GSM8583580 Cas9-NTC3 Cas9-NTC
- GSM8583581 Cas9-Gli2KO1 Cas9-Gli2KO
- GSM8583582 Cas9-Gli2KO2 Cas9-Gli2KO
- GSM8583583 Cas9-Gli2KO3 Cas9-Gli2KO
- GSE279937 Gli2 Facilitates Tumor Immune Evasion and Immunotherapeutic Resistance by Coordinating Wnt Ligand and Prostaglandin Synthesis [scRNAseq] 8 samples shares gli2, immunotherapeutic, prostaglandin, coordinating, facilitates, resistance, evasion, ligand
- GSE279936 Gli2 Facilitates Tumor Immune Evasion and Immunotherapeutic Resistance by Coordinating Wnt Ligand and Prostaglandin Signaling [Sorted_tumor_DC RNAseq] 6 samples shares gli2, immunotherapeutic, prostaglandin, coordinating, facilitates, resistance, evasion, ligand
- GSE279934 Gli2 Facilitates Tumor Immune Evasion and Immunotherapeutic Resistance by Coordinating Wnt Ligand and Prostaglandin Signaling [Bulk_Tumor_RNAseq] 6 samples shares gli2, immunotherapeutic, prostaglandin, coordinating, facilitates, resistance, evasion, ligand
- GSE281427 Non-canonical Hedgehog signaling via GLI2 promotes pancreatic stellate cell activation and fibrosis in chronic pancreatitis 6 samples shares gli2
- GSE274496 Bulk RNA-sequencing of Meibomian glands from K5-rtTA tetO-GLI2DN mice and littermate controls 6 samples shares gli2
- GSE329979 Spatiotemporal Role of GLI2 in Driving SHH-Medulloblastoma Tumorigenesis 5 samples shares gli2
- GSE267749 Positive regulation of Hedgehog signaling via phosphorylation of GLI2/GLI3 by DYRK2 kinase 4 samples shares gli2
- GSE294647 Specific and redundant roles for Gli2 and Gli3 in establishing cell fate during hair follicle development 2 samples shares gli2
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.