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RNA Sequencing Analysis of NCAPD2 Knockdown in Lung Adenocarcinoma Cell Line PC9

GSE280143 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/02/24 Platform GPL16791
Summary
This study investigates the effect of NCAPD2 knockdown on lung adenocarcinoma (LUAD) by performing RNA sequencing on PC9 cell lines. The experiment included three control PC9 cells and three PC9 cells in which NCAPD2 was knocked down using shRNA. This RNA sequencing experiment aims to elucidate the role of NCAPD2 in regulating gene expression associated with tumor proliferation, migration, and survival in LUAD. Analysis of differential gene expression provides insights into the pathways affected by NCAPD2 knockdown, with an emphasis on signaling pathways critical to LUAD progression, such as the PI3K/AKT pathway.
Published in
NCAPD2 promotes the progression of lung adenocarcinoma through an AKT/MDM2/E2F1 positive feedback loop
Wu Y, Li X, Lin Y et al. · Cancer biology & therapy 2025 · PMID 41319185 · doi:10.1080/15384047.2025.2589678
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Direct links to NCBI, no account and no request form: the whole study as GSE280143_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1176543 and SRA study SRP540406. Searching any of these in the dataset finder brings you back here.

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