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SOAT1 knockout reshapes tumor immune microenvironment with enhanced CD8+ T cell infiltration and effector function [scRNA-seq]

GSE280149 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2025/12/31 Platform GPL28457
Summary
To investigate the mechanism, we performed single-cell RNA sequencing (scRNA-seq) to profile the in vivo transcriptome and immune landscape (Figure 4F). Tumors from PBS- and anti-PD1-treated mice were purified using Ficoll and subjected to scRNA-seq, recovering 9,431 and 9,970 cells from SOAT1-KO tumors, and 10,880 and 8,580 cells from vector tumors, respectively.
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Also filed as BioProject PRJNA1176551 and SRA study SRP540435. Searching any of these in the dataset finder brings you back here.

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