Impact of Early Bisphenol A Exposure on Transcriptome and Chromatin Accessibility in Brain Oligodendrocytes of Juvenile Mice [RNA-seq]
RNA-seq (gene expression) · mouse · 16 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 16 samples: 4 × O4, male, control, RNA, vs 4 × O4, female, control, RNA, vs 4 × O4, male, BPA, RNA, vs 4 × O4, female, BPA, RNA,Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Bisphenol A exposure during gestation and lactation in mice: Sex-specific consequences on oligodendrocytes and myelinationToxicology · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE280174_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1176694 and SRA study SRP540466. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 16 samples.
How we read this: 4 replicated groups read from 16 sample titles; they account for 16 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8591159 O4, male, control, RNA, rep1 O4, male, control, RNA,
- GSM8591160 O4, male, control, RNA, rep2 O4, male, control, RNA,
- GSM8591161 O4, male, control, RNA, rep3 O4, male, control, RNA,
- GSM8591162 O4, male, control, RNA, rep4 O4, male, control, RNA,
- GSM8591163 O4, female, control, RNA, rep1 O4, female, control, RN…
- GSM8591164 O4, female, control, RNA, rep2 O4, female, control, RN…
- GSM8591165 O4, female, control, RNA, rep3 O4, female, control, RN…
- GSM8591166 O4, female, control, RNA, rep4 O4, female, control, RN…
- GSM8591167 O4, male, BPA, RNA, rep1 O4, male, BPA, RNA,
- GSM8591168 O4, male, BPA, RNA, rep2 O4, male, BPA, RNA,
- GSM8591169 O4, male, BPA, RNA, rep3 O4, male, BPA, RNA,
- GSM8591170 O4, male, BPA, RNA, rep4 O4, male, BPA, RNA,
- GSM8591171 O4, female, BPA, RNA, rep1 O4, female, BPA, RNA,
- GSM8591172 O4, female, BPA, RNA, rep2 O4, female, BPA, RNA,
- GSM8591173 O4, female, BPA, RNA, rep3 O4, female, BPA, RNA,
- GSM8591174 O4, female, BPA, RNA, rep4 O4, female, BPA, RNA,
- GSE283483 Novel environment exposure drives temporally defined and region-specific chromatin accessibility and gene expression programs in the hippocampus 160 samples shares accessibility, chromatin, exposure
- GSE166225 Inference of emergent spatio-temporal processes from single-cell sequencing reveals feedback between de novo DNA methylation and chromatin condensates [RNA-seq] 288 samples shares chromatin, rna-seq
- GSE290224 Intermittent Fasting Reprograms Chromatin Accessibility to Modulate Gene Expression in Brain and Muscle 96 samples shares accessibility, chromatin
- GSE299114 Endothelial Cells retain inflammatory memory through chromatin remodeling [RNA-Seq 2] 53 samples shares chromatin, rna-seq
- GSE234248 Systematic assessment of ISWI subunits reveals that NURF creates local accessibility for CTCF [RNA-seq] 24 samples shares accessibility, rna-seq
- GSE283086 Distinct transcriptomic and epigenomic responses of mature oligodendrocytes during disease progression in a mouse model of multiple sclerosis [RNA-seq] 15 samples shares oligodendrocytes, rna-seq
- GSE216371 A single-cell atlas of chromatin accessibility in mouse organogenesis 68 samples shares accessibility, chromatin
- GSE309545 Inflammatory signaling differentially changes chromatin accessibility and gene expression of the PD-associated kinase LRRK2 between human and mice [multiome mouse] 64 samples shares accessibility, chromatin
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.