GEO series
Molecular Cartography of the Human and Mouse Down Syndrome Brain [snRNA-seq]
GSE280175
Homo sapiens
Expression profiling by high throughput sequencing
10 samples
2025/07/11
GPL24676
Summary
To gain molecular insight into the prenatal neurobiology of DS, we performed single-nucleus sequencing, spatial transcriptomics, and proteomics on mid-gestational prenatal human brain tissue. We captured altered expression dynamics of lineage commitment genes in DS neural progenitor cells, which suggest changes to the fate and functionality of neuronal and glial cells.
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Paper (PMID 41027953) ↗
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