Histone variant H2BE controls activity-dependent gene expression and homeostatic scaling [RNA-seq]
Single-nucleus RNA-seq · mouse · 24 samples
- What it is
- Single-nucleus RNA-seqGene activity measured in individual nuclei (used when whole cells are hard to isolate, for example from frozen tissue). Read from the summary: GEO's own type field only says 'expression profiling by sequencing', so confirm it in the paper.
- Organism
- Mus musculus (mouse)
- Samples
- 24 samples
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Histone variant H2BE controls activity-dependent gene expression and homeostatic scalingCell reports · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE280190_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Single-cell studies usually ship their counts as 10x files (matrix.mtx, barcodes.tsv, features.tsv), an .h5 file, or an .rds / .h5ad object that Seurat or Scanpy can open. Look for those among the supplementary files.
Also filed as BioProject PRJNA1176974 and SRA study SRP540486. Searching any of these in the dataset finder brings you back here.
The sample list for this study is not cached yet. Press Load samples and it will be fetched from NCBI.
+ 24 more — browse all 24 samples with per-sample file links →
- GSE308556 RNA-seq analysis of neurons overexpressing histone variant H2BE and stimulated with BDNF 10 samples shares h2be, histone, variant, rna-seq
- GSE246688 CUT&Tag, ATAC-seq, bulk RNA-seq and single-nucleus RNA-seq analysis of histone variant H2BE in cortical neurons 67 samples shares h2be, histone, variant, rna-seq
- GSE246739 ATAC-seq analysis of histone variant H2BE in neuronal chromatin 25 samples shares h2be, histone, variant
- GSE308557 CUT&Tag seq analysis of histone variant H2BE in stimulated neurons 10 samples shares h2be, histone, variant
- GSE244066 Argonaute3-SF3B3 complex controls pre-mRNA splicing to restrain Type-2 immunity [RNA-seq: dissected tissues] 78 samples shares controls, rna-seq
- GSE227844 MicroRNA-150 controls experimental autoimmune encephalomyelitis by regulating CD4 T cell differentiation and function [RNA-seq II] 44 samples shares controls, rna-seq
- GSE296482 A cell-intrinsic glucocorticoid biosynthesis and sensing circuit maintains homeostatic Th17 cell state [RNA-seq] 31 samples shares homeostatic, rna-seq
- GSE276607 The retrotransposable element-silencing factor Daxx controls microglia identity and function in the adult brain [RNA-seq] 30 samples shares controls, rna-seq
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.