ONECUT2 reprograms neuroendocrine fate and is an actionable therapeutic target in small cell lung cancer.
RNA-seq (gene expression) · human · 24 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Topic
- Small cell lung cancerThis series is part of our curated briefing on it.
- Samples
- 24 samples: 8 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- ONECUT2 reprograms neuroendocrine fate and is an actionable therapeutic target in small cell lung cancerMolecular medicine (Cambridge, Mass.) · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE280219_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1177381 and SRA study SRP540619. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 24 samples.
How we read this: 8 replicated groups read from 24 sample titles; they account for 24 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8592371 C_1 C
- GSM8592372 C_2 C
- GSM8592373 C_3 C
- GSM8592374 OE_1 OE
- GSM8592375 OE_2 OE
- GSM8592376 OE_3 OE
- GSM8592377 OE_t1_1 OE_t1
- GSM8592378 OE_t1_2 OE_t1
- GSM8592379 OE_t1_3 OE_t1
- GSM8592380 C_t1_1 C_t1
- GSM8592381 C_t1_2 C_t1
- GSM8592382 C_t1_3 C_t1
- GSM8592383 OE_t2_1 OE_t2
- GSM8592384 OE_t2_2 OE_t2
- GSM8592385 OE_t2_3 OE_t2
- GSM8592386 C_t2_1 C_t2
- GSM8592387 C_t2_2 C_t2
- GSM8592388 C_t2_3 C_t2
- GSM8592389 OE_t3_1 OE_t3
- GSM8592390 OE_t3_2 OE_t3
- GSM8592391 OE_t3_3 OE_t3
- GSM8592392 C_t3_1 C_t3
- GSM8592393 C_t3_2 C_t3
- GSM8592394 C_t3_3 C_t3
- GSE273409 DNAPKCs as a therapeutic target in small cell lung cancer 36 samples same disease briefing · shares therapeutic, target, small
- GSE267310 Microenvironment Shapes Small Cell Lung Cancer Neuroendocrine States and Presents Therapeutic Opportunities 12 samples same disease briefing · shares neuroendocrine, therapeutic, small
- GSE268219 Phase separation of RXRγ drives tumor chemoresistance and represents a therapeutic target for small cell lung cancer [RNA-Seq] 8 samples same disease briefing · shares therapeutic, target, small
- GSE281782 Novel therapeutic strategy targeting STMN1 using chlorambucil-conjugated pyrrole-imidazole polyamide in small cell lung cancer 4 samples same disease briefing · shares therapeutic, target, small
- GSE259271 Therapeutic targeting ERRγ suppresses metastasis via extracellular matrix remodeling in small cell lung cancer (RNA-Seq) 3 samples same disease briefing · shares therapeutic, target, small
- GSE259273 Therapeutic targeting ERRγ suppresses metastasis via extracellular matrix remodeling in small cell lung cancer 7 samples same disease briefing · shares therapeutic, target, small
- GSE259272 Therapeutic targeting ERRγ suppresses metastasis via extracellular matrix remodeling in small cell lung cancer (ChIP-Seq) 4 samples same disease briefing · shares therapeutic, target, small
- GSE279100 Differential KEAP1/NRF2-mediated signaling widens the therapeutic window of redox-targeting drugs in SCLC therapy [seq] 50 samples same disease briefing · shares therapeutic, target
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.