Deep sequencing of microRNA and total RNA reveals distinct microRNA-mRNA signatures that differentiate pancreatic neuroendocrine neoplasia from non-diseased pancreas tissue [RNA-seq]
RNA-seq (gene expression) · human · 13 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 13 samples: 13 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Deep sequencing reveals distinct microRNA-mRNA signatures that differentiate pancreatic neuroendocrine tumor from non-diseased pancreas tissueBMC cancer · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE280271_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1177494 and SRA study SRP540699. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 13 sample titles: 13 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8593720 P1, tumor [RNA-seq]
- GSM8593721 P2, tumor [RNA-seq]
- GSM8593722 P3, tumor [RNA-seq]
- GSM8593723 P4, tumor [RNA-seq]
- GSM8593724 P5, tumor [RNA-seq]
- GSM8593725 P6, tumor [RNA-seq]
- GSM8593726 P7, non-diseased [RNA-seq]
- GSM8593727 P8, non-diseased [RNA-seq]
- GSM8593728 P10, non-diseased [RNA-seq]
- GSM8593729 P11, non-diseased [RNA-seq]
- GSM8593730 P12, non-diseased [RNA-seq]
- GSM8593731 P13, non-diseased [RNA-seq]
- GSM8593732 P14, non-diseased [RNA-seq]
- GSE281039 Molecular characterization of pancreatic neuroendocrine tumor tissue: characterization of altered pathways and potential non-invasive biomarkers 40 samples shares neuroendocrine, pancreatic
- GSE296486 Tumor-derived Apolipoprotein E induces Tip endothelial cell to remodel tumor stroma ratio and promote pancreatic neuroendocrine tumor progression 34 samples shares neuroendocrine, pancreatic
- GSE301075 Immunosuppressive myeloid signaling and distinct malignant cell states in pancreatic neuroendocrine tumors revealed by single-nucleus RNA-seq 21 samples shares neuroendocrine, pancreatic
- GSE275775 Time courses analysis of the effect of latrunculin B-treatment on gene expression in in vitro differentiated pancreatic progenitor cells. 16 samples shares differentiate, pancreatic
- GSE267722 MUC1-C DEPENDENCE FOR PROGRESSION OF PANCREATIC NEUROENDOCRINE TUMORS IDENTIFIES A DRUGGABLE TARGET FOR TREATMENT OF THIS RARE CANCER 12 samples shares neuroendocrine, pancreatic
- GSE323363 Inhibition of SIRT7 Overcomes Radioresistance in Pancreatic Neuroendocrine Tumors by Reactivating MEN1 Expression 12 samples shares neuroendocrine, pancreatic
- GSE293843 Targeting the ferritinophagy-lysosome axis as a therapeutic vulnerability in gastroenteropancreatic neuroendocrine tumors [RNA-Seq] 10 samples shares neuroendocrine, pancreatic
- GSE326578 Menin-RelA complex antagonizes cancer cell-intrinsic and tumour microenvironment-induced NF-κB hyperactivation to suppress pancreatic neuroendocrine tumorigenesis 8 samples shares neuroendocrine, pancreatic
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.