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Normoxia and Hypoxia transcriptomics

GSE280308 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/07/09 Platform GPL24676
Summary
Hypoxia leads to the aggregation of PD-L1 on the cell membrane without altering the overall protein expression level of PD-L1. Identify differentially expressed genes in the hypoxic transcriptome to reveal the key proteins involved in PD-L1 membrane trafficking, using samples of SCC25 cells treated with normoxia and hypoxia for 12 hours.
Published in
Elucidating the role of N-myristoylation in the excessive membrane localization of PD-L1 in hypoxic cancers and developing a novel NMT1 inhibitor for combination with immune checkpoint blockade therapy
Zhao H, Zhang Z, Zhang C et al. · Journal of experimental & clinical cancer research : CR 2025 · PMID 40605065 · doi:10.1186/s13046-025-03438-z
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Also filed as BioProject PRJNA1177809 and SRA study SRP540827. Searching any of these in the dataset finder brings you back here.

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