Increased pulmonary blood flow leads to alveolar dysplasia at early postnatal developmental stage
RNA-seq (gene expression) · mouse · 10 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 10 samples: 5 × p14_ipf vs 5 × p14_shamGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Increased pulmonary blood flow leads to alveolar dysplasia during the early postnatal developmental stageCell & bioscience · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE280388_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1178287 and SRA study SRP541431. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 10 samples.
How we read this: 2 replicated groups read from 10 sample titles; they account for 10 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8596587 p14_ipf_1 p14_ipf
- GSM8596588 p14_ipf_2 p14_ipf
- GSM8596589 p14_ipf_3 p14_ipf
- GSM8596590 p14_ipf_4 p14_ipf
- GSM8596591 p14_ipf_5 p14_ipf
- GSM8596592 p14_sham_1 p14_sham
- GSM8596593 p14_sham_2 p14_sham
- GSM8596594 p14_sham_3 p14_sham
- GSM8596595 p14_sham_4 p14_sham
- GSM8596596 p14_sham_5 p14_sham
- GSE271971 Pulmonary microvascular endothelial cells support alveolar epithelial growth via bone morphogenetic protein 6 secretion 72 samples shares pulmonary, alveolar
- GSE330728 Single-nucleus RNA-seq atlas of 17 ASD-risk mouse lines under early-postnatal fluoxetine or lithium exposure (4-plex On-Chip Multiplexed) 53 samples shares postnatal, early
- GSE186649 A mitochondrial long-chain fatty acid oxidation defect in a mouse leads to dysregulation of plasma long-chain acylcarnitines, dysregulation of plasma amino acids, and an increased reliance on glucocorticoid signaling to maintain euglycemia during fasting 50 samples shares increased, leads
- GSE310138 Sex-Biased Transcription in Early Postnatal Layer 2/3 Cortical Neurons: Interplay Between Sex and Cux1/2 Mutations 43 samples shares postnatal, early
- GSE314207 Alveolar Macrophages Undergo a Postnatal Transition from a Hyperphagocytic and Proinflammatory Profile to a Tolerogenic Profile 24 samples shares postnatal, alveolar
- GSE317613 pH-Responsive Nanostructured Calcium Phosphate Microrods as Pulmonary Delivery Platform: Fabrication, Characterization, and Comparative Assessment of Cytotoxic and Transcriptomic Responses in Alveolar Macrophages 15 samples shares pulmonary, alveolar
- GSE241109 Loss of the C-terminus of p63 leads to an increased expression of extracellular matrix genes in keratinocytes [RNA-seq] 14 samples shares increased, leads
- GSE289897 Loss of Tbx4 Affects Postnatal Lung Development and Predisposes to Pulmonary Hypertension 12 samples shares pulmonary, postnatal
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.