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Investigation of genes involoved in Corydalis incisa (Thunb.) Pers. (CIP)-induced differentiation in acute myeloid leukemia (AML).

GSE280425 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/02/26 Platform GPL21697
Summary
Acute myeloid leukemia (AML) is the most common form of leukemia in adults. Differentiation therapy targets the key pathologic features of AML, the blockade of differentiation in myeloid progenitor cells. This study screened 100 plant extracts native to South Korea to search for those with differentiation-inducing activity in AML. Of these, Corydalis incisa (Thunb.) Pers. (CIP) exhibited the highest efficacy.CIP induced myeloid differentiation, decreased cell viability, increased cell apoptosis, and cell cycle arrest in multiple AML cell lines. We performed Quantseq 3' mRNA seqencing to understand CIP-induced differentiation and identify potential targets of CIP using CIP-resistant cell line.
Published in
Norchelerythrine from Corydalis incisa (Thunb.) Pers. promotes differentiation and apoptosis by activating DNA damage response in acute myeloid leukemia
Lee JE, Jeon BE, Kwon CS et al. · International journal of oncology 2025 · PMID 39918000 · doi:10.3892/ijo.2025.5723
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Also filed as BioProject PRJNA1178566 and SRA study SRP541527. Searching any of these in the dataset finder brings you back here.

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