Effect of Sirt2 deletion in mouse hepatocytes on gene experession in mouse livers overexpressed with GFP or MET/CAT

There is a gap in our understanding of mechanisms promoting hepatocellular carcinoma (HCC), and this limits our ability to provide targeted therapy interventions for HCC. In HCC samples, NAD-dependent deacetylase sirtuin 2 (SIRT2) levels are increased and associated with a significantly worse prognosis, but the role of SIRT2 in hepatocarcinInogenesis remains controversial. In this study, we investigated the role of SIRT2 in HCC development and examined the effect of Sirt2 deletion in hepatocytes on gene expression in mouse livers overexpressed with GFP control or MET/CAT.