Differential KEAP1/NRF2-mediated signaling widens the therapeutic window of redox-targeting drugs in SCLC therapy
Expression microarray · human · 74 samples
- What it is
- Expression microarrayGene activity read on a chip (the older technology that RNA-seq replaced).
- Organism
- Homo sapiens (human)
- Topic
- Small cell lung cancerThis series is part of our curated briefing on it.
- Samples
- 74 samples: 18 conditions, mostly with about 5 replicates eachGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed expression table (series matrix) and the array files, from NCBI.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE280643_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For arrays the series matrix is normally the normalised expression table you want; the raw array files (CEL and similar) are in the RAW.tar.
Also filed as BioProject PRJNA1179864 and SRA study SRP537355. Searching any of these in the dataset finder brings you back here.
Supports a case/control comparison: 5 samples read as cases, 32 as controls.
How we read this: 18 replicated groups read from 74 sample titles; they account for 74 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8561447 Tumor vehicle biol rep 1 Tumor vehicle biol
- GSM8561448 Tumor vehicle biol rep 2 Tumor vehicle biol
- GSM8561449 Tumor vehicle biol rep 3 Tumor vehicle biol
- GSM8561450 Tumor vehicle biol rep 4 Tumor vehicle biol
- GSM8561451 Tumor vehicle biol rep 5 Tumor vehicle biol
- GSM8561452 Tumor CDDO biol rep 1 Tumor CDDO biol
- GSM8561453 Tumor CDDO biol rep 2 Tumor CDDO biol
- GSM8561454 Tumor CDDO biol rep 3 Tumor CDDO biol
- GSM8561455 Tumor CDDO biol rep 4 Tumor CDDO biol
- GSM8561456 Tumor CDDO biol rep 5 Tumor CDDO biol
- GSM8561457 Heart vehicle biol rep 1 Heart vehicle biol
- GSM8561458 Heart vehicle biol rep 2 Heart vehicle biol
- GSM8561459 Heart vehicle biol rep 3 Heart vehicle biol
- GSM8561460 Heart vehicle biol rep 4 Heart vehicle biol
- GSM8561461 Heart vehicle biol rep 5 Heart vehicle biol
- GSM8561462 Heart CDDO biol rep 1 Heart CDDO biol
- GSM8561463 Heart CDDO biol rep 2 Heart CDDO biol
- GSM8561464 Heart CDDO biol rep 3 Heart CDDO biol
- GSM8561465 Heart CDDO biol rep 4 Heart CDDO biol
- GSM8561466 Heart CDDO biol rep 5 Heart CDDO biol
- GSM8561467 Kidney vehicle biol rep 1 Kidney vehicle biol
- GSM8561468 Kidney vehicle biol rep 2 Kidney vehicle biol
- GSM8561469 Kidney vehicle biol rep 3 Kidney vehicle biol
- GSM8561470 Kidney vehicle biol rep 4 Kidney vehicle biol
- GSM8561471 Kidney vehicle biol rep 5 Kidney vehicle biol
- GSM8561472 Kidney CDDO biol rep 1 Kidney CDDO biol
- GSM8561473 Kidney CDDO biol rep 2 Kidney CDDO biol
- GSM8561474 Kidney CDDO biol rep 3 Kidney CDDO biol
- GSM8561475 Kidney CDDO biol rep 4 Kidney CDDO biol
- GSM8561476 Kidney CDDO biol rep 5 Kidney CDDO biol
- GSM8561477 Liver vehicle biol rep 1 Liver vehicle biol
- GSM8561478 Liver vehicle biol rep 2 Liver vehicle biol
- GSM8561479 Liver vehicle biol rep 3 Liver vehicle biol
- GSM8561480 Liver vehicle biol rep 4 Liver vehicle biol
- GSM8561481 Liver vehicle biol rep 5 Liver vehicle biol
- GSM8561482 Liver CDDO biol rep 1 Liver CDDO biol
- GSM8561483 Liver CDDO biol rep 2 Liver CDDO biol
- GSM8561484 Liver CDDO biol rep 3 Liver CDDO biol
- GSM8561485 Liver CDDO biol rep 4 Liver CDDO biol
- GSM8561486 Liver CDDO biol rep 5 Liver CDDO biol
+ 34 more — browse all 74 samples with per-sample file links →
- GSE279100 Differential KEAP1/NRF2-mediated signaling widens the therapeutic window of redox-targeting drugs in SCLC therapy [seq] 50 samples same disease briefing · shares keap1, sclc, redox-targeting, nrf2-mediated, differential, therapeutic, therapy, widens
- GSE267928 Teriflunomide/leflunomide synergize with chemotherapeutics by decreasing mitochondrial fragmentation via DRP1 in SCLC 12 samples same disease briefing · shares sclc, therapeutic
- GSE272002 LSD1 inhibitor, TAS1440, disrupts INSM1-LSD1 complex activating tumor-suppressive pathways via transcriptional reprogramming in neuroendocrine SCLC 324 samples same disease briefing · shares sclc
- GSE66298 A DNA Hypomethylation Signature Predicts Novel Anti-Tumor Activity of LSD1 Inhibitors in SCLC 136 samples same disease briefing · shares sclc
- GSE255095 An in vivo screening platform using PDX models reveals KEAP1, USP22 and other drivers of chemoresistance in small cell lung cancer 67 samples same disease briefing · shares keap1
- GSE149507 Microarray expression data of 18 pairs of small cell lung cancer (sclc) and tumor and adjacent lung tissues 36 samples same disease briefing · shares sclc
- GSE64766 Selective Loss of RB in Resistant EGFR Mutant Lung Adenocarcinomas that Transform to SCLC 16 samples same disease briefing · shares sclc
- GSE245123 A key netwrok hub gene GRN confers chemo resistance in H2081 SCLC cells. 6 samples same disease briefing · shares sclc
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.