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RBM10 Deficiency Promotes Brain Metastasis by Modulating Sphingolipid Metabolism in an Animal Model of EGFR Mutation Lung Adenocarcinoma

GSE280915 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/03/19 Platform GPL24676
Summary
Brain metastasis significantly contributes to the failure of targeted therapy in patients with EGFR-mutated lung adenocarcinoma (LUAD). Reduced expression of RBM10 is associated with brain metastasis in these patients. However, the mechanism by which RBM10 affects brain metastasis in EGFR-mutated LUAD remains unclear. Previous studies reveal that RBM10 mutations lead to decreased expression and deregulated splicing at a subset of junctions, primarily through exon skipping.
Published in
RBM10 deficiency promotes brain metastasis by modulating sphingolipid metabolism in a BBB model of EGFR mutant lung adenocarcinoma
Xu G, An B, Wang R et al. · Journal of experimental & clinical cancer research : CR 2025 · PMID 40069781 · doi:10.1186/s13046-025-03347-1
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Also filed as BioProject PRJNA1181035 and SRA study SRP542694. Searching any of these in the dataset finder brings you back here.

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