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Recapitulating cartilaginous organoids and hypoxic metabolic switching via adaptive stem cell-matrix interactions promotes histone lactylation and cartilage regeneration

GSE280956 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing 4 samples Submitted 2025/03/26 Platform GPL24676
Summary
The formation of cartilaginous organoids fostered by the cell–hydrogel adaptation creates a hypoxic microenvironment and induces metabolic switching to favor glycolysis and the accumulation of lactate in the MSC spheroids, leading to significantly elevated histone lysine lactylation (Kla). We further show that the increased H3K18la enhances chondrogenesis and cartilaginous matrix deposition by regulating the transcriptional accessibility of chondrogenic genes.
Published in
Recapitulating hypoxic metabolism in cartilaginous organoids via adaptive cell-matrix interactions enhances histone lactylation and cartilage regeneration
Yang B, Li Z, Yang Z et al. · Nature communications 2025 · PMID 40108220 · doi:10.1038/s41467-025-57779-6
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Also filed as BioProject PRJNA1181530 and SRA study SRP542817. Searching any of these in the dataset finder brings you back here.

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