Dual targeting CDK4/6 and CDK7 augments tumor response and anti-tumor immunity in breast cancer
RNA-seq (gene expression) · human · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Topic
- Breast cancerThis series is part of our curated briefing on it.
- Samples
- 12 samples: 12 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Dual targeting of CDK4/6 and CDK7 augments tumor response and antitumor immunity in breast cancer modelsThe Journal of clinical investigation · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE281158_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1182401 and SRA study SRP543360. Searching any of these in the dataset finder brings you back here.
Supports a case/control comparison: 2 samples read as cases, 2 as controls.
How we read this: Read from 12 sample titles: 12 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8611914 AT3-OVA Tumor Control (biol rep 1)
- GSM8611915 AT3-OVA Tumor CDK4/6i+CDK7i (biol rep 1)
- GSM8611916 AT3-OVA Tumor Control (biol rep 2)
- GSM8611917 AT3-OVA Tumor CDK4/6i+CDK7i (biol rep 2)
- GSM8625257 MDA-MB-231 Control (biol rep 1)
- GSM8625258 MDA-MB-231 CDK4/6i (biol rep 1)
- GSM8625259 MDA-MB-231 CDK7i (biol rep 1)
- GSM8625260 MDA-MB-231 CDK4/6i+CDK7i (biol rep 2)
- GSM8625261 MDA-MB-231 CDK4/6i+CDK7i (biol rep 1)
- GSM8625262 MDA-MB-231 CDK4/6i (biol rep 2)
- GSM8625263 MDA-MB-231 CDK7i (biol rep 2)
- GSM8625264 MDA-MB-231 Control (biol rep 2)
- GSE104193 Hypoxia-mediated translational activation of ITGB3 in breast cancer cells enhances TGF-β signalling and malignant features in vitro and in vivo 32 samples same disease briefing · shares breast
- GSE104675 Role for the Transcriptional Activator ZRF1 in Breast Cancer Progression and Endocrine Resistance 6 samples same disease briefing · shares breast
- GSE10886 A Supervised Risk Predictor of Breast Cancer Based on Biological Subtypes 226 samples same disease briefing · shares breast
- GSE11121 The humoral immune system has a key prognostic impact in node-negative breast cancer 200 samples same disease briefing · shares breast
- GSE10885 An integromic analysis reveals that metaplastic carcinomas are distinct from basal-like tumors. 244 samples same disease briefing
- GSE242839 PD-1 is induced on tumor-associated macrophages in obesity to directly restrain anti-tumor immunity 29 samples shares anti-tumor, immunity
- GSE310025 Intrinsic RB activation induces tumoral and stromal anti-tumor responses that limit triple-negative breast cancer [RNA-Seq] 28 samples shares anti-tumor, breast
- GSE270229 Inhibition of miR-10b treats metastatic breast cancer by targeting stem cell-like properties 18 samples shares targeting, breast
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.