GEO series
Transcriptomic profiling of signet ring cell precursors of diffuse-type gastric cancer informs latent phenotype
GSE281274
Homo sapiens
Expression profiling by high throughput sequencing
20 samples
2025/02/21
GPL24676
Summary
Germline CDH1 loss-of-function mutations are causally linked to an increased lifetime risk of diffuse gastric cancer (DGC). Early, multifocal signet ring cell (SRC) lesions are ubiquitous among CDH1 variant carriers, yet only a subset of patients will develop advanced DGC. Transcriptomic profiling was performed to establish the molecular phenotype of early SRC lesions.
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Paper (PMID 40192595) ↗
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