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Single-cell multi-omic analysis of post-transplant mesenchymal cells reveals molecular signatures and regulators of lung fibrosis (RNA-seq)

GSE281481 Homo sapiens Expression profiling by high throughput sequencing 8 samples Submitted 2026/03/29 Platform GPL34284
Summary
Chronic lung allograft dysfunction (CLAD) is a critical challenge in lung transplantation. Dysregulated gene expression and epigenomic states in lung mesenchymal cells (MCs) play a key role in these conditions. We performed single-cell multi-omic profiling on MCs isolated from human bronchoalveolar lavage samples of lung transplant recipients with CLAD, compared with time-matched controls. Our results provide deeper insights into the transcriptomic and epigenomic changes in post-transplant MCs, nominating biomarkers and disease-associated factors with implications for future therapeutic efforts.
Published in
Single-cell multiomic analysis of mesenchymal cells reveals molecular signatures and regulators of lung allograft fibrosis
Lu L, McLinden AP, Walker NM et al. · JCI insight 2026 · PMID 42044158 · doi:10.1172/jci.insight.196651
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Also filed as BioProject PRJNA1184115 and SRA study SRP544199. Searching any of these in the dataset finder brings you back here.

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