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Transcriptional regulation of adipocyte lipolysis by IRF2BP2 [RNA-seq]

GSE281493 Homo sapiens Expression profiling by high throughput sequencing 8 samples Submitted 2024/11/14 Platform GPL24676
Summary
Adipocyte lipolysis controls systemic energy levels and metabolic homeostasis. Lipolysis is regulated by post-translational modifications of key lipolytic enzymes. However, less is known about the transcriptional mechanisms that regulate lipolysis. Here, we identify the transcriptional factor interferon regulatory factor-2 binding protein 2 (IRF2BP2) as a repressor of adipocyte lipolysis. Deletion of IRF2BP2 in primary human adipocytes increases lipolysis without affecting glucose uptake, whereas IRF2BP2 overexpression decreases lipolysis. RNA-seq and ChIP-seq analyses reveal that IRF2BP2 directly represses several lipolysis-related genes, including LIPE (HSL, hormone sensitive lipase), which encodes the rate-limiting enzyme in lipolysis. Adipocyte-selective deletion of Irf2bp2 in mice increases Lipe expression and free fatty acid levels, resulting in elevated adipose tissue inflammation and glucose intolerance. Altogether, these findings demonstrate that IRF2BP2 restrains adipocyte lipolysis and opens new avenues to target lipolysis for the treatment of metabolic disease.
Published in
Transcriptional regulation of adipocyte lipolysis by IRF2BP2
Chen Y, Liu L, Calhoun R et al. · Science advances 2025 · PMID 39752494 · doi:10.1126/sciadv.ads5963
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Also filed as BioProject PRJNA1184141 and SRA study SRP544220. Searching any of these in the dataset finder brings you back here.

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