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The role of RUNX2 and BHLHE40 in pathologically relevant CD4 positive tissue-resident T-cells in Crohn's disease. (CITE-seq, CD4+ CD103+ T cell)

GSE281509 Homo sapiens Expression profiling by high throughput sequencing; Other 6 samples Submitted 2025/08/14 Platform GPL24676
Summary
Tissue-resident T-cells (TRM) are deeply involved in immune memory at the site of inflammation. Here, we identified two key transcription factors, RUNX2 and BHLHE40 as regulators of pathologically relevant CD4-positive TRM in the inflamed gut mucosa of Crohn’s disease patients.
Published in
Multi-omics uncovers transcriptional programs of gut-resident memory CD4+ T cells in Crohn's disease
Arase M, Murakami M, Kihara T et al. · The Journal of experimental medicine 2025 · PMID 40906156 · doi:10.1084/jem.20242106
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Also filed as BioProject PRJNA1184161 and SRA study SRP544240. Searching any of these in the dataset finder brings you back here.

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