GEO series
Human ChIP-seq of three metastatic Patient-Derived-Organoid (PDO)
GSE281582
Homo sapiens
Genome binding/occupancy profiling by high throughput sequencing
17 samples
2026/03/27
GPL18573
Summary
A key problem in cancer biology is understanding the phenotypic characteristics of the aggressive cell states present in macrometastases and their molecular underpinnings. Here we report on the cellular constituents of human breast cancer metastases, revealing that these malignant cells are invariably locked in a chimeric cell state. Human BC metastatic cells indeed display a gene-expression profile associated to embryonic development of tubular organs, while also retaining the transcriptional features of their original adult mammary luminal lineage.
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NCBI GEO page ↗
Paper (PMID 41923644) ↗
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