Engineering Bi-directional Chemically-modulated Synthetic Condensates for Cellular Control
RNA-seq (gene expression) · human · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 12 samples: 3 × blank HEK293 cells vs 3 × HEK293 cells stably expressing ARDrop-ALK vs 3 × HEK293 cells stably expressing ARDrop-ALK_3 treated with DMSO for 2 hours vs 3 × HEK293 cells stably expressing ARDrop-ALK_3 treated with BICA for 2 hoursGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Engineering bi-directional chemically-modulated synthetic condensates for cellular controlNature communications · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE281634_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1184702 and SRA study SRP544438. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 4 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8625145 blank HEK293 cells_1 blank HEK293 cells
- GSM8625146 blank HEK293 cells_2 blank HEK293 cells
- GSM8625147 blank HEK293 cells_3 blank HEK293 cells
- GSM8625148 HEK293 cells stably expressing ARDrop-ALK_ 1 HEK293 cells stably exp…
- GSM8625149 HEK293 cells stably expressing ARDrop-ALK_ 2 HEK293 cells stably exp…
- GSM8625150 HEK293 cells stably expressing ARDrop-ALK_ 3 HEK293 cells stably exp…
- GSM8625151 HEK293 cells stably expressing ARDrop-ALK_3 treated with DMSO for 2 hours_ 1 HEK293 cells stably exp…
- GSM8625152 HEK293 cells stably expressing ARDrop-ALK_3 treated with DMSO for 2 hours_ 2 HEK293 cells stably exp…
- GSM8625153 HEK293 cells stably expressing ARDrop-ALK_3 treated with DMSO for 2 hours_ 3 HEK293 cells stably exp…
- GSM8625154 HEK293 cells stably expressing ARDrop-ALK_3 treated with BICA for 2 hours_ 1 HEK293 cells stably exp…
- GSM8625155 HEK293 cells stably expressing ARDrop-ALK_3 treated with BICA for 2 hours_ 2 HEK293 cells stably exp…
- GSM8625156 HEK293 cells stably expressing ARDrop-ALK_3 treated with BICA for 2 hours_ 3 HEK293 cells stably exp…
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Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.