Proteomic study identifies Aurora-A mediated regulation of alternative splicing through multiple splicing factors
RNA-seq (gene expression) · human · 20 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 20 samples: 10 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Proteomic study identifies Aurora-A-mediated regulation of alternative splicing through multiple splicing factorsThe Journal of biological chemistry · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE281881_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1186114 and SRA study SRP545232. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 20 samples.
How we read this: 10 replicated groups read from 20 sample titles; they account for 20 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8631723 Set1 mRNA-seq of HEK293T cells with DMSO, Replicate1 Set1 mRNA-seq of HEK293…
- GSM8631724 Set1 mRNA-seq of HEK293T cells with DMSO, Replicate2 Set1 mRNA-seq of HEK293…
- GSM8631725 Set1 mRNA-seq of HEK293T cells with MLN8237, Replicate1 Set1 mRNA-seq of HEK293…
- GSM8631726 Set1 mRNA-seq of HEK293T cells with MLN8237, Replicate2 Set1 mRNA-seq of HEK293…
- GSM8631727 Set2 mRNA-seq of HEK293T cells with siNT1, Replicate1 Set2 mRNA-seq of HEK293…
- GSM8631728 Set2 mRNA-seq of HEK293T cells with siNT1, Replicate2 Set2 mRNA-seq of HEK293…
- GSM8631729 Set2 mRNA-seq of HEK293T cells with siSF3B5, Replicate1 Set2 mRNA-seq of HEK293…
- GSM8631730 Set2 mRNA-seq of HEK293T cells with siSF3B5, Replicate2 Set2 mRNA-seq of HEK293…
- GSM8631731 Set2 mRNA-seq of HEK293T cells with siSRSF1, Replicate1 Set2 mRNA-seq of HEK293…
- GSM8631732 Set2 mRNA-seq of HEK293T cells with siSRSF1, Replicate2 Set2 mRNA-seq of HEK293…
- GSM8631733 Set2 mRNA-seq of HEK293T cells with siSRSF2, Replicate1 Set2 mRNA-seq of HEK293…
- GSM8631734 Set2 mRNA-seq of HEK293T cells with siSRSF2, Replicate2 Set2 mRNA-seq of HEK293…
- GSM8631735 Set2 mRNA-seq of HEK293T cells with siSRSF7, Replicate1 Set2 mRNA-seq of HEK293…
- GSM8631736 Set2 mRNA-seq of HEK293T cells with siSRSF7, Replicate2 Set2 mRNA-seq of HEK293…
- GSM8631737 Set3 mRNA-seq of HEK293T cells with siNT2, Replicate 1 Set3 mRNA-seq of HEK293…
- GSM8631738 Set3 mRNA-seq of HEK293T cells with siNT2, Replicate 2 Set3 mRNA-seq of HEK293…
- GSM8631739 Set3 mRNA-seq of HEK293T cells with siRBM39, Replicate1 Set3 mRNA-seq of HEK293…
- GSM8631740 Set3 mRNA-seq of HEK293T cells with siRBM39, Replicate2 Set3 mRNA-seq of HEK293…
- GSM8631741 Set3 mRNA-seq of HEK293T cells with siSRSF3, Replicate1 Set3 mRNA-seq of HEK293…
- GSM8631742 Set3 mRNA-seq of HEK293T cells with siSRSF3, Replicate2 Set3 mRNA-seq of HEK293…
- GSE330179 mRNA-seq analysis of S100A16-mediated alternative splicing in lung adenocarcinoma under oxidative stress 18 samples shares alternative, mediated, splicing
- GSE246916 MORC2 regulates RBM39-mediated CDK5RAP2 alternative splicing to promote EMT and metastasis in colon cancer 14 samples shares alternative, mediated, splicing
- GSE334651 Alternative splicing- and gene fusion-derived neoepitopes in MASLD-associated hepatocellular carcinoma 120 samples shares alternative, splicing
- GSE268177 Modulating alternative splicing of MECP2: A potential therapeutic strategy for Rett syndrome 93 samples shares alternative, splicing
- GSE297994 Native long-read RNA sequencing of human monocytes reveals activation-induced alternative splicing toward functional isoforms 22 samples shares alternative, splicing
- GSE269596 Multiplexed single-cell characterization of alternative polyadenylation regulators (scRNA-Seq) 12 samples shares alternative, multiple
- GSE100638 Large-scale tethering of RNA binding proteins discovers alternative splicing regulators 220 samples shares alternative, splicing
- GSE278751 A stem cell model identifies two alternative cell fates in CBFA2T3::GLIS2-driven acute megakaryoblastic leukemia initiation (Multiome scRNA-seq/scATAC-seq) 14 samples shares alternative, identifies
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.