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Gene expression profile of hypoxia-treated IOMM-Lee cells (malignant grade 3 meningioma cells)

GSE282349 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2026/02/18 Platform GPL24676
Summary
Tumor development relies on numerous factors, including the capacity to adapt to hypoxic conditions. Hypoxic microenvironment is a critical driver of the malignant phenotype, which is often correlated with meningioma grade, aggressive behavior, therapeutic resistance, and higher recurrence rates, leading to poor prognosis. Hence, the exploration of genes involved in tumor adaptation to hypoxia can reveal novel molecular targets for the development of hypoxia-targeted therapeutics for meningioma.
Published in
Novel insights into hypoxia-driven transcriptomic and epigenetic landscapes in grade 3 meningioma
Dalal M, Joshi R, Ajithkumar P et al. · Journal of translational medicine 2025 · PMID 41437098 · doi:10.1186/s12967-025-07606-9
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Also filed as BioProject PRJNA1188171 and SRA study SRP546254. Searching any of these in the dataset finder brings you back here.

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