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Gene expression analysis of human parotid salivary glands in cases of Mucoepidermoid Carcinoma via bulk RNA sequencing

GSE282430 Homo sapiens (human) RNA-seq (gene expression) 28 samples Submitted 2025/05/16 Platform GPL16791
At a glance

RNA-seq (gene expression) · human · 28 samples

What it is
RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
Organism
Homo sapiens (human)
Samples
28 samples: 22 × humanTumo vs 6 × humanNormalGroups are read from the sample names, not from the paper. Check the list below.
Data you can get
A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Paper
Correction: An FGFR-p53 developmental signaling axis drives salivary cancer progressionOncogene · 2025
Summary (written by the submitters)
Mucoepidermoid carcinoma (MEC) is the most frequently occurring salivary gland malignancy. Here, we investigated transcriptomic profiles of human adult salivary glands and MEC tumors to assess programs involved in MEC progression. MEC tumors were stratified by disease grade and CRTC1/MAML2 fusion status. The bioinformatics of our study will provide critical steps in elucidating salivary MEC progression and suggest a new candidates for targeted therapies in the treatment of high-grade MEC.
Published in
Correction: An FGFR-p53 developmental signaling axis drives salivary cancer progression
Musicant AM, Billington JMR, Damrauer JS et al. · Oncogene 2025 · PMID 40542202 · doi:10.1038/s41388-025-03478-x
This dataset
Open GSE282430 in finder → Find more human RNA-seq datasets →
Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓
2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE282430_RAW.tar (it can run to tens of gigabytes).

All supplementary files ↗ Whole study · RAW.tar ↓
3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

Raw reads on ENA ↗

What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.

Also filed as BioProject PRJNA1188576 and SRA study SRP546511. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 40542202) ↗
Study design
22 × humanTumo vs 6 × humanNormal

Supports a between-group comparison across 28 samples.

How we read this: 2 replicated groups read from 28 sample titles; they account for 28 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.

Samples in this study
Datasets on a similar topic

Search all human RNA-seq datasets in GEO →

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Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.