GEO series

Childhood brain tumors instructs cranial haematopoiesis and immunotolerance

GSE282459 Mus musculus Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing 8 samples Submitted 2025/12/01 Platform GPL24247

Summary

ZFTA-RELA ependymoma poses a formidable challenge due to limited treatment avenues, prompting exploration into immunotherapeutic approaches. Recent investigations have shed light on the calvaria bone marrow as a source of meningeal immune cells crucial for central nervous system (CNS) immunity. Whether or not cues from the tumour microenvironment can instruct local haematopoiesis within the skull is unknown. We used single cell RNA sequencing (snRNAseq + snATAC) to analyze the dynamic transcriptional regulation of skull, peripheral bone marrow from tumour-bearing and non-tumour bearing ZFTA-RELA fusion driven ependymoma mice.

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Also filed as BioProject PRJNA1188615 and SRA study SRP546564. Searching any of these in the dataset finder brings you back here.

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