Splicing Factor 3a Subunit 1 Promotes Colorectal Cancer Growth via Anti-programmed cell death of Syntaxin12.

SF3A1 is a subunit of the SF3a complex, an integral component of U2 snRNP, playing a crucial role in intron recognition and pre-RNA splicing during the splicing process. Notably, we observed that SF3A1 exerts its growth-promoting effects specifically in cancer cells, despite no discernible alteration in expression levels between tumor and normal cells. Genetic mutations in SF3A1 may play a role in pancreatic cancer development, and a reported correlation exists between SF3A1 gene polymorphisms and colorectal cancer (CRC) risk. However, the specific mRNAs with which SF3A1 interacts in CRC and whether this interaction is directly implicated in tumor growth remain unclear. In this study, our purpose was to elucidate the mechanisms of SF3A1-mediated tumor progression in colorectal cancer cells.