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RACK7 Senses and Fine-Tunes Enhancer Activity [Chromatin associated RNA-seq]

GSE282513 Homo sapiens Expression profiling by high throughput sequencing 8 samples Submitted 2025/07/03 Platform GPL24676
Summary
Enhancers regulate dynamic gene expression in a spatiotemporal specific manner. A number of positive as well as negative regulators of enhancers have been reported so far. However, whether and how these regulators sense enhancer activity dynamics remains unclear. In this study, we show that a specific enhancer regulator, RACK7, swiftly re-distributes from repressed enhancers to activated enhancers in response to a plethora of acute stimulations. We further show that this process depends on transcription and RACK7 positively regulates enhancer activation by promoting the recruitment of RNA polymerase II. Taken together, our findings suggest that RACK7 senses enhancer activity changes and facilitates their activation during acute stimulations.
Published in
RACK7 senses and fine-tunes enhancer activity
Dong L, Zhang D, Cai Y et al. · iScience 2025 · PMID 40734674 · doi:10.1016/j.isci.2025.113083
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Also filed as BioProject PRJNA1189069 and SRA study SRP546777. Searching any of these in the dataset finder brings you back here.

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