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Gene expression profiling of MDA-MB-231 cells treated Compound 28, a CDK9 degrader

GSE282602 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2024/11/27 Platform GPL34281
Summary
Triple-negative breast cancer (TNBC) is highlyaggressive with very limited treatment options due to the lack of efficient targeted therapies and thus still remains clinically challenging. Targeting CDK9 to remodel transcriptional regulation shows great promisein cancer therapy. We synthesized new series of heterobifunctional molecules ashighly selective and efficacious CDK9 degraders, enabling potentinhibition of TNBC cell growth and rapidly targeted degradationof CDK9. Moreover, the CDK9 degrader (compound 28) was used to treat on TNBC cell lines and the gene expression profile was performed by RNA-seq.
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Also filed as BioProject PRJNA1189447 and SRA study SRP546984. Searching any of these in the dataset finder brings you back here.

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