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REG3A promotes the development of pancreatic cancer by activating EGFR pathway

GSE282763 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/02/26 Platform GPL11154
Summary
REG3A is highly expressed in pancreatic tissues, but its significance is unclear. We found that REG3A overexpressed in paracancerous acinar cells interacted with EGFR on tumor cells to stimulate downstream tumor growth signals and promote the occurrence and development of tumors
Published in
REG3A secreted by peritumoral acinar cells enhances pancreatic ductal adenocarcinoma progression via activation of EGFR signaling
Ren X, Teng Y, Xie K et al. · Cell communication and signaling : CCS 2025 · PMID 39966859 · doi:10.1186/s12964-025-02103-4
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Also filed as BioProject PRJNA1190379 and SRA study SRP547395. Searching any of these in the dataset finder brings you back here.

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