Eosinophils restrict CRC metastasis by inhibiting pro-tumorigenic Spp1+ macrophage differentiation.
RNA-seq (gene expression) · human · 42 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Topic
- Colorectal cancerThis series is part of our curated briefing on it.
- Samples
- 42 samples: 42 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE282765_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1190381 and SRA study SRP627970. Searching any of these in the dataset finder brings you back here.
Supports a case/control comparison: 8 samples read as cases, 11 as controls.
How we read this: Read from 42 sample titles: 42 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8650167 Human healthy blood eosinophils, replicate 1, scRNAseq
- GSM8650168 Human healthy blood eosinophils, replicate 2, scRNAseq
- GSM8650169 Human healthy blood eosinophils, replicate 3, scRNAseq
- GSM8650170 Human healthy blood eosinophils, replicate 4, scRNAseq
- GSM8650171 Human healthy blood eosinophils, replicate 5, scRNAseq
- GSM8650172 Human healthy blood eosinophils, replicate 6, scRNAseq
- GSM8650173 Human CRC tumor CD45 pos, replicate 1, scRNAseq
- GSM8650174 Human CRC NAT CD45 pos, replicate 1, scRNAseq
- GSM8650175 Human CRC tumor CD45 pos, replicate 2, scRNAseq
- GSM8650176 Human CRC NAT CD45 pos, replicate 2, scRNAseq
- GSM8650177 Human CRC tumor CD45 pos, replicate 3, scRNAseq
- GSM8650178 Human CRC NAT CD45 pos, replicate 3, scRNAseq
- GSM8650179 Human CRC tumor CD45 pos, replicate 4, scRNAseq
- GSM8650180 Human CRC NAT CD45 pos, replicate 4, scRNAseq
- GSM8650181 Human CRC tumor CD45 pos, replicate 5, scRNAseq
- GSM8650182 Human CRC NAT CD45 pos, replicate 5, scRNAseq
- GSM8650183 Human CRC tumor CD45 pos, replicate 6, scRNAseq
- GSM8650184 Human CRC NAT CD45 pos, replicate 6, scRNAseq
- GSM8650185 Human CRC tumor CD45 pos, replicate 7, scRNAseq
- GSM8650186 Human CRC NAT CD45 pos, replicate 7, scRNAseq
- GSM8696919 Mouse blood and bone marrow from healthy and AKPS tumor mice eosinophils, scRNAseq
- GSM8696920 Mouse colon no tumor WT and PHIL CD45 pos, scRNAseq
- GSM8696921 Mouse tumor PHIL, NAT WT and disseminated tumor PHIL and WT CD45 pos, scRNAseq
- GSM8696922 Mouse tumor AKPS WT CD45 pos, scRNAseq
- GSM8696923 Sample tag library associated with Mouse blood and bone marrow from healthy and AKPS tumor mice eosinophils,ST, scRNAseq
- GSM8696924 Sample tag library associate with Mouse colon no tumor WT and PHIL CD45 pos, ST, scRNAseq
- GSM8696925 Sample tag library associated with Mouse tumor PHIL, NAT WT and disseminated tumor PHIL and WT CD45 pos, ST, scRNAseq
- GSM9207392 Human healthy blood eosinophils, replicate 7, scRNAseq
- GSM9207393 Human healthy blood eosinophils, replicate 8, scRNAseq
- GSM9207394 Human healthy blood eosinophils, replicate 9, scRNAseq
- GSM9207395 Human healthy blood eosinophils, replicate 10, scRNAseq
- GSM9207396 Human CRC blood eosinophils, replicate 1, scRNAseq
- GSM9207397 Human CRC blood eosinophils, replicate 2, scRNAseq
- GSM9207398 Human CRC blood eosinophils, replicate 3, scRNAseq
- GSM9207399 Human CRC blood eosinophils, replicate 4, scRNAseq
- GSM9207400 Human CRC blood eosinophils, replicate 5, scRNAseq
- GSM9207401 Human CRC blood eosinophils, replicate 6, scRNAseq
- GSM9207402 Human CRC blood eosinophils, replicate 7, scRNAseq
- GSM9270242 Mouse NAT and tumor isotype and anti-IL5 treated AKPS CD45 negative, WTA, scRNAseq
- GSM9270243 Mouse colon Citrobacter rodentium CD45 pos, WTA, scRNAseq
+ 2 more — browse all 42 samples with per-sample file links →
- GSE250000 Bulk RNA-sequencing of transduced colorectal cancer cell line HCT-116 and breast cancer cell line MCF-7 overexpressing full-lenght p53β or p53β-stop-lost. 4 samples same disease briefing
- GSE12032 Inherent gene signature of stage II and III colorectal cancer leads in individual recurrence 198 samples same disease briefing
- GSE109308 Single-cell transcriptomic survey of adenomatous polyposis patients with germline APC mutations 97 samples same disease briefing
- GSE110009 Single cell transcriptome landscape of primary and metastatic tumor in colon cancer 76 samples same disease briefing
- GSE262088 Human-Specific Elimination of Epithelial Siglec-XII Suppresses the Risk of CRC Initiation and Progression 21 samples shares crc
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.