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LIS1 promotes perineural invasion by upregulating the serine metabolism in head and neck squamous carcinoma

GSE282822 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/01/01 Platform GPL24676
Summary
LIS1 is a critical mediator of neuronal migration during brain development, and is strongly associated with malignant tumors. We found that LIS1 is highly expressed in HNSCC,which is releated to perineural infiltration(PNI) in HNSCC.To explore the mechanism of PNI, we silenced the LIS1 expression in HNSCC cells and dected the function of PNI.In a word,We sought to validate LIS1 as a key signaling molecule for PNI in HNSCC.
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Also filed as BioProject PRJNA1189856 and SRA study SRP547194. Searching any of these in the dataset finder brings you back here.

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