← BioTransfer GEO Dataset Finder
GEO series

ZNF296 drives immune evasion in epithelial cancer cells [ATAC-seq]

GSE283057 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing 6 samples Submitted 2025/09/06 Platform GPL24676
Summary
Using a genome-wide CRISPR activation screen, we identified ZNF296, a transcription factor prominently expressed in epithelial cancers, as a key regulator of tumor resistance to NK cell-mediated cytotoxicity. To investigate the role of ZNF296 in regulating chromatin accessibility and its effects on gene transcription, we performed ATAC-seq on ZNF296-overexpressing (ZNF296-OE) and control A549 cells. These data provide insights into the epigenetic mechanisms underlying ZNF296-mediated tumor immune evasion.
Published in
ZNF296 Drives Immune Evasion in Epithelial Cancers by Repressing Immune Stimulatory Genes
Wang H, Zhao F, Li Y et al. · Cancer research 2026 · PMID 40991281 · doi:10.1158/0008-5472.CAN-25-0153
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE283057_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1191518 and SRA study SRP548101. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 6 more — browse all 6 samples with per-sample file links →

Similar datasets

Search all human ChIP / ATAC / CUT&Tag datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.