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Atheroprotective immunity and interleukin-10 linked to reduced plaque stability and recurrent cardiovascular events

GSE283077 Mus musculus (mouse) RNA-seq (gene expression) 14 samples Submitted 2025/07/30 Platform GPL21103
At a glance

RNA-seq (gene expression) · mouse · 14 samples

What it is
RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
Organism
Mus musculus (mouse)
Samples
14 samples: 4 × HuBL live vs 4 × BT3xHuBL live vs 3 × HuBL aorta vs 3 × BT3xHuBL aortaGroups are read from the sample names, not from the paper. Check the list below.
Data you can get
A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Paper
Atheroprotective Immunity and Interleukin-10 Linked to Reduced Characteristics of Plaque StabilityJACC. Basic to translational science · 2025
Summary (written by the submitters)
Atherosclerotic cardiovascular disease remains a major cause of death worldwide. Autoimmunity to low-density lipoprotein (LDL) has been implicated in the disease process and immunization with LDL components proposed as a preventive strategy. However, mechanisms of atheroprotective immunity remain insufficiently characterized. Two different T cell receptor transgenic mouse strains with T cells reactive against the LDL protein, apoB100 (BT1 and BT3) were crossbred with human APOB100-transgenic Ldlr-/- (HuBL) mice, and atherosclerosis was evaluated.
Read the full summary ↓
In 52-week-old BT1xHuBL mice, a lower atherosclerotic burden was observed in the aorta, mirrored by reduced plasma cholesterol and elevated anti-apoB100 antibodies. BT3xHuBL mice also exhibited a decrease in aortic atherosclerosis; however, no reduction in plasma cholesterol levels was noted. Instead, type 1 regulatory T cell responses with interleukin (IL)-10 production were mounted. This response was associated with reduced collagen content and a lower stability index of the atherosclerotic lesions. In human carotid artery plaques, IL10 mRNA levels were negatively correlated with collagen expression, and IL-10 was found to inhibit collagen production in vascular smooth muscle cells. We conclude that atheroprotective apoB immunity elicits two distinct pathways: lipid-lowering immune reactions and local anti-inflammatory IL-10 production. Since the latter is associated with decreased plaque stability and cardiovascular events, treatments aimed at increasing IL-10 signaling over extended periods to reduce vascular inflammation need reconsideration.
Published in
Atheroprotective Immunity and Interleukin-10 Linked to Reduced Characteristics of Plaque Stability
Yu Y, Lin S, Pan Y et al. · JACC. Basic to translational science 2025 · PMID 40674844 · doi:10.1016/j.jacbts.2025.101322
This dataset
Open GSE283077 in finder → Find more mouse RNA-seq datasets →
Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓
2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE283077_RAW.tar (it can run to tens of gigabytes).

All supplementary files ↗ Whole study · RAW.tar ↓
3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

Raw reads on ENA ↗

What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.

Also filed as BioProject PRJNA1191829 and SRA study SRP548208. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 40674844) ↗
Study design
4 × HuBL live vs 4 × BT3xHuBL live vs 3 × HuBL aorta vs 3 × BT3xHuBL aorta

Supports a between-group comparison across 14 samples.

How we read this: 4 replicated groups read from 14 sample titles; they account for 14 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.

Samples in this study
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