GEO series
SH2D1A Promotes CHI3L2 Expression and Facilitates the Progression of T-Cell Acute Lymphoblastic Leukemia
GSE283165
Homo sapiens
Expression profiling by high throughput sequencing
16 samples
2025/04/21
GPL24676
Summary
T-cell acute lymphoblastic leukemia (T-ALL) is a highly aggressive hematologic malignancy. The potential of investigating SH2D1A holds promise for more targeted therapies and better outcomes. Knocking down SH2D1A led to decreased T-ALL cell survival and growth both in vitro and in vivo. RNA-seq analysis was conducted and the differently expressed genes were revealed in the SH2D1A-knockdown Jurkat and 6T-CEM cells in comparison to control group.
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Paper (PMID 40233919) ↗
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