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TGM2-mediated histone serotonylation promotes HCC progression via MYC signalling pathway [RNA-Seq]

GSE283279 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2024/12/16 Platform GPL24676
Summary
Hepatocellular carcinoma (HCC) is a formidable malignancy with limited effective therapeutic avenues. This study was designed to investigate the role of transglutaminase 2 (TGM2) in promoting HCC progression and assess its potential as a target for therapeutic intervention in HCC treatment.TMG2 expression was positively related to a higher AFP level, poor differentiation, and a later BCLC stage. Tgm2 deficiency or H3Q5ser inhibition notably restrained HCC progression. Mechanism research revealed that TGM2-mediated H3Q5ser modifications promote HCC progression via MYC pathway signaling. Furthermore, transcriptional intermediary factor 1 beta (TIF1-β/TRIM28) mediated the recruitment of TGM2 by MYC to facilitate H3Q5ser modifications on MYC targets. Finally, targeting the TGM2 transglutaminase activity significantly suppressed HCC progression in preclinical models.
Published in
TGM2-mediated histone serotonylation promotes HCC progression via MYC signalling pathway
Dong R, Wang T, Dong W et al. · Journal of hepatology 2025 · PMID 39788430 · doi:10.1016/j.jhep.2024.12.038
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Also filed as BioProject PRJNA1186337 and SRA study SRP545720. Searching any of these in the dataset finder brings you back here.

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