GEO series
Analysis of gene regulation by the TP63 isoforms deltaNp63alpha and deltaNp63beta using ChIPseq of p63 and H3K27ac
GSE283359
Homo sapiens
Genome binding/occupancy profiling by high throughput sequencing
11 samples
2024/12/13
GPL18573
Summary
Our goal was to assess transcriptional changes of the colon carcinoma cell line HCT116 TP53-/- in response to expression of the TP63 isoforms deltaNp63alpha or deltaNp63beta. The goal was to understand how these C-terminal isoforms of p63 might differentially regulate gene expression. We also assessed how differential binding of these isoforms and how they affect local changes in H3K27ac.
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Paper (PMID 40545896) ↗
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