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Genetically Engineered Brain Organoids Recapitulate Spatial and Developmental States of Glioblastoma Progression [scRNA-seq]

GSE283496 Homo sapiens Expression profiling by high throughput sequencing 4 samples Submitted 2025/03/19 Platform GPL24676
Summary
This study develops engineered glioblastoma organoids (eGBOs) to investigate the role of specific mutations in tumor progression. The analytic framework spans single-cell analysis, spatial transcriptomics, single-cell trajectory analysis, orthotopic implantation, clinically oriented imaging, and histopathological analysis. The work provides an important proof of concept that engineered tumor organoids can model glioblastoma progression.
Published in
Genetically Engineered Brain Organoids Recapitulate Spatial and Developmental States of Glioblastoma Progression
Ishahak M, Han RH, Annamalai D et al. · Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 · PMID 39836549 · doi:10.1002/advs.202410110
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Direct links to NCBI, no account and no request form: the whole study as GSE283496_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 4 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1194110 and SRA study SRP549349. Searching any of these in the dataset finder brings you back here.

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