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Single-cell multi-omics analysis identifies metabolism-linked epigenetic reprogramming as a driver of therapy-resistant medulloblastoma [PDX Multiome]

GSE283606 Homo sapiens Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing 8 samples Submitted 2025/09/01 Platform GPL24676
Summary
We perform scMultiomic sequencing on matched patient primary and recurrent tumors. We identify a unique population of cells that is metabolically and epigenetically altered. We recapitulate this population of cells in in vivo radiation resistant models. Disruption of this population with wtIDH1 inhibitors suppresses growth and re-sensitizes cells to irradiation.
Published in
Single-cell multi-omics identifies metabolism-linked epigenetic reprogramming as a driver of therapy-resistant medulloblastoma
Veo B, Wang D, DeSisto J et al. · Nature communications 2025 · PMID 41290646 · doi:10.1038/s41467-025-65466-9
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Also filed as BioProject PRJNA1194607 and SRA study SRP549646. Searching any of these in the dataset finder brings you back here.

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