BCL11A is required for normal erythropoiesis
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 74 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Samples
- 74 samples: 56 distinct titles, 16 of them repeatedGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- BCL11A-deficient human erythropoiesis is impaired in vitro and after xenotransplantation into miceBlood advances · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE283797_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1195589 and SRA study SRP550076. Searching any of these in the dataset finder brings you back here.
How we read this: Read from 74 sample titles: 56 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8672379 UT_D7_CD71_1_2157373
- GSM8672380 UT_D7_ProE_1_2157374
- GSM8672381 UT_D7_BasoE_1_2157375
- GSM8672382 UT_D7_CD71_2_2157376
- GSM8672383 UT_D7_ProE_2_2157377
- GSM8672384 UT_D7_BasoE_2_2157378
- GSM8672385 g1617_D7_CD71_1_2157379
- GSM8672386 g1617_D7_ProE_1_2157380
- GSM8672387 g1617_D7_BasoE_1_2157381
- GSM8672388 g1617_D7_CD71_2_2157382
- GSM8672389 g1617_D7_ProE_2_2157383
- GSM8672390 g1617_D7_BasoE_2_2157384
- GSM8672391 UT_D7_CD71_1_2196621
- GSM8672392 UT_D7_ProE_1_2196622
- GSM8672393 UT_D7_BasoE_1_2196623
- GSM8672394 UT_D7_CD71_2_2196624
- GSM8672395 UT_D7_ProE_2_2196625
- GSM8672396 UT_D7_BasoE_2_2196626
- GSM8672397 g1617_D7_CD71_1_2196627
- GSM8672398 g1617_D7_ProE_1_2196628
- GSM8672399 g1617_D7_BasoE_1_2196629
- GSM8672400 g1617_D7_CD71_2_2196630
- GSM8672401 g1617_D7_ProE_2_2196631
- GSM8672402 g1617_D7_BasoE_2_2196632
- GSM8672403 CD34_Day10_IgG
- GSM8672404 CD34_Day10_BCL11A_CutRun_1
- GSM8672405 CD34_Day10_BCL11A_CutRun_2
- GSM8672406 CD34_Day7_BCL11A_CutRun_1
- GSM8672407 CD34_Day7_BCL11A_CutRun_2
- GSM8672408 CD34_Day7_IgG
- GSM8672409 NT_2
- GSM8672410 NT_1
- GSM8672411 NT_3
- GSM8672412 BCL11AKO_1
- GSM8672413 BCL11AKO_2
- GSM8672414 BCL11AKO_3
- GSM8672415 Dnr10_UT_D7_CD71_0_2003912
- GSM8672416 Dnr10_gCD33_D7_CD71_0_2003913
- GSM8672417 Dnr10_g1617_D7_CD71_0_2003914
- GSM8672418 Dnr10_g34_D7_CD71_0_2003917
+ 34 more — browse all 74 samples with per-sample file links →
- GSE274928 The glucocorticoid receptor elicited proliferative response in human erythropoiesis is BCL11A-dependent 51 samples shares bcl11a, erythropoiesis
- GSE201822 CTCF is selectively required for maintaining chromatin accessibility and gene expression in human erythropoiesis 60 samples shares erythropoiesis, required
- GSE201820 CTCF is selectively required for maintaining chromatin accessibility and gene expression in human erythropoiesis [H2_HiC] 8 samples shares erythropoiesis, required
- GSE292698 Silencing of BCL11A by Disrupting Enhancer-Dependent Chromatin Insulation 95 samples shares bcl11a
- GSE292753 Analysis of chromatin occupancy in erythroid cells by CUT&RUN following CRISPR editing of BCL11A enhancer 33 samples shares bcl11a
- GSE291384 Multiplex base editing of BCL11A regulatory elements to treat sickle cell disease 12 samples shares bcl11a
- GSE277215 Insights into intestinal neuroendocrine tumors in relation to normal human EEC differentiation 53 samples shares normal
- GSE271687 Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal and malignant urothelial cells 38 samples shares normal
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.