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Single-cell RNA-sequencing analysis reveals the peripheral immune characteristics of patients with primary membranous nephropathy

GSE283826 Homo sapiens Expression profiling by high throughput sequencing 9 samples Submitted 2025/09/10 Platform GPL24676
Summary
Primary Membranous Nephropathy (PMN) is characterized by dysregulated immune responses, with B and T cells playing critical roles in disease pathogenesis. While significant strides have been made in identifying specific autoantigens and leveraging monoclonal antibodies, the precise immunopathogenic mechanisms underlying immune cell involvement in PMN remain elusive. To comprehensively characterize the cellular, molecular, and immunological landscape, we employed single-cell RNA sequencing (scRNA-seq) on peripheral blood mononuclear cell samples (PBMC) obtained from 6 patients with PMN and 3 healthy controls (NC).We examined the heterogeneity and functional diversity of B cells in PMN. These results offer new insight into pathogenesis and identify new therapeutic targets for PMN.
Published in
Exploring immunological alterations of B cells in peripheral immunity via single-cell RNA sequencing: insights into primary membranous nephropathy
Lu F, Chen S, Guo H et al. · Frontiers in immunology 2025 · PMID 40904455 · doi:10.3389/fimmu.2025.1622395
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Also filed as BioProject PRJNA1195830 and SRA study SRP550209. Searching any of these in the dataset finder brings you back here.

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