GEO series
Transcriptional readthrough and splicing upon chemotherapy treatment [long-read, nascent RNA]
GSE283849
Homo sapiens
Expression profiling by high throughput sequencing
18 samples
2026/02/15
GPL21311GPL34382
Summary
The Neugebauer lab has previously shown that splicing occurs co-transcriptionally and is coupled to 3’end cleavage. It is known that stress, such as hyperosmotic shock, affects RNA processing. The cellular stress response is an important component of cancer cell response to chemotherapy that can determine cell survival. Herein, we study how the coupling of the RNA processes in leukemia cells is affected in response to stress and therapeutic agents. We used short- and long-read sequencing to follow RNA processing upon treatment.
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Paper (PMID 41279586) ↗
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