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Changes of energy metabolism-related proteins before and after donor liver transplantation in patients with ischemia-reperfusion injury

GSE283907 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/01/23 Platform GPL34284
Summary
To investigate the molecular mechanisms underlying ischemia-reperfusion (IR) injury in liver transplantation, RNA sequencing (RNA-seq) was performed on liver specimens obtained at various stages: before ischemia and post-reperfusion. The RNA-seq analysis aimed to profile gene expression changes in response to IR injury and identify key molecular pathways involved in liver dysfunction, with a particular focus on energy metabolism-related proteins PPARα. This approach provides a comprehensive understanding of the transcriptional alterations that occur during liver transplantation, highlighting the changes in metabolic pathways such as gluconeogenesis and fatty acid oxidation. These findings may offer insights into therapeutic strategies for mitigating IR-induced damage and enhancing liver transplantation outcomes by targeting energy metabolism pathways.
Published in
Mild hypothermia attenuates hepatic ischemia-reperfusion injury by regulating FoxO1/PPARα pathway
Lu Z, Chen H, Liu A et al. · Scientific reports 2025 · PMID 40770269 · doi:10.1038/s41598-025-09725-1
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Also filed as BioProject PRJNA1194977 and SRA study SRP549938. Searching any of these in the dataset finder brings you back here.

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