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R-2-hydroxyglutarate-mediated inhibition of KDM4A disrupts telomere integrity

GSE283914 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing 6 samples Submitted 2025/05/27 Platform GPL11154
Summary
Isocitrate dehydrogenases 1 and 2 are mutated in more than 70% of low-grade glioma. This promotes the production of R-2-hydroxyglutarate (R-2HG) instead of α-ketoglutarate (αKG) and R-2HG will inhibit α-ketoglutarate enzymes like the lysine demethylase KDM4A. We hypothesized that KDM4A inhibition through R-2HG contribute to gliomagenesis. In our study, we showed that KDM4A inhibition leads to telomere defects. By ChIP-seq experiments, we demonstrated that KDM4A localized on telomeric repeats and that its depletion increased the level of H3K9me3 on telomeric chromatin.
Published in
R-2-hydroxyglutarate-mediated inhibition of KDM4A compromises telomere integrity
Couteau F, Gagné LM, Boulay K et al. · Nucleic acids research 2025 · PMID 40498073 · doi:10.1093/nar/gkaf512
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Also filed as BioProject PRJNA1196302 and SRA study SRP550420. Searching any of these in the dataset finder brings you back here.

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