GEO series
Progesterone receptor and the RNA polymerase III subunit POLR3A co-occupy tRNAs in breast cancer cells
GSE283979
Homo sapiens
Genome binding/occupancy profiling by high throughput sequencing
14 samples
2025/09/29
GPL16791
Summary
Progesterone receptors (PR) can regulate transcription by RNA Polymerase III (Pol III), which transcribes small non-coding RNAs, including all transfer RNAs (tRNAs). This and previous work demonstrated that PR associates with the Pol III complex at tRNA genes and that progestins downregulate tRNA transcripts in breast tumor models.
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Paper (PMID 41206048) ↗
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