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Symbiotic Adhesion of Neutrophils and Epithelial-like Cancer Cells Shapes the Tumor Microenvironment and Promotes Metastasis [2]

GSE284278 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2026/05/19 Platform GPL19057
Summary
Neutrophils play complicated roles in tumor progression. Examination of several murine triple negative breast cancer (TNBC) models revealed nearly opposite impact of neutrophils on epithelial-like vs. mesenchymal-like cancer cells (ECCs vs. MCCs). Interaction with ECCs upregulates ICAM1 in neutrophils, a feature that also distinguishes tumor-infiltrating neutrophils from other neutrophils in human. Direct adhesion between ECCs and neutrophils, especially the ICAMhigh subpopulation, promote the survival of each other – forming a symbiotic relationship. In contrast, MCCs are thwarted by neutrophils due to decreased cell adhesion and elastase resistance. The ICAM1high neutrophils are known for reverse migration to circulation. The adhesive and reverse migratory properties of ICAM1high neutrophils mediate intravasation of metastatic seeds. These observations were verified in a subset of human TNBCs that unexpectedly enrich non-Hispanic European patients. Thus, we demonstrated a co-evolution through which neutrophils sculpt phenotypes and metastatic behaviors of TNBC, which may preferentially occur in patients of certain race/ethnicity.
Published in
ICAM1high Neutrophils Sculpt Tumor Evolution and Metastasis Through Symbiotic Adhesion and Reverse Migration
Wu L, Xu Z, Wang J et al. · Cancer research 2026 · PMID 42207963 · doi:10.1158/0008-5472.CAN-25-3935
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Also filed as BioProject PRJNA1198328 and SRA study SRP551445. Searching any of these in the dataset finder brings you back here.

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