GEO series
IRE1α Downregulation Enhances STING-Mediated Chemoresistance and Guides Precision Therapies in Pancreatic Cancer
GSE284365
Mus musculus
Expression profiling by high throughput sequencing; Other
12 samples
2025/09/03
GPL34290
Summary
The cGAS-STING signaling pathway plays dichotomous roles in the development of malignant diseases. While the role and regulation of STING signaling in immune cells is well-documented, the mechanisms by which tumor cells modify tumor-intrinsic STING signaling to evade treatment remain poorly understood. Here, we report that chemotherapy activates STING and induces low-grade chronic inflammation in pancreatic ductal adenocarcinoma (PDAC) cells.
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