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Early precursor-derived pituitary gland tissue-resident macrophages play a pivotal role in modulating hormonal balance

GSE284385 Mus musculus (mouse) Single-cell RNA-seq 12 samples Submitted 2025/01/03 Platform GPL24247
At a glance

Single-cell RNA-seq · mouse · 12 samples

What it is
Single-cell RNA-seqGene activity measured in thousands of individual cells, so cell types can be told apart. Read from the summary: GEO's own type field only says 'expression profiling by sequencing', so confirm it in the paper.
Organism
Mus musculus (mouse)
Samples
12 samples: 4 × pituitary gland, isotype control, biol vs 4 × pituitary gland, anti-CD115 depletion, biolGroups are read from the sample names, not from the paper. Check the list below.
Data you can get
A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Paper
Early precursor-derived pituitary gland tissue-resident macrophages play a pivotal role in modulating hormonal balanceCell reports · 2025
SuperSeries — this record groups several sub-series.
Summary (written by the submitters)
This SuperSeries is composed of the scRNA-Seq and bulk RNA-Seq SubSeries listed below.
Published in
Early precursor-derived pituitary gland tissue-resident macrophages play a pivotal role in modulating hormonal balance
Lehtonen H, Jokela H, Hofmann J et al. · Cell reports 2025 · PMID 39841599 · doi:10.1016/j.celrep.2024.115227
This dataset
Open GSE284385 in finder → Find more mouse RNA-seq datasets →
Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓
2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE284385_RAW.tar (it can run to tens of gigabytes).

All supplementary files ↗ Whole study · RAW.tar ↓
3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

Raw reads on ENA ↗

What the files usually look like: Single-cell studies usually ship their counts as 10x files (matrix.mtx, barcodes.tsv, features.tsv), an .h5 file, or an .rds / .h5ad object that Seurat or Scanpy can open. Look for those among the supplementary files.

Also filed as BioProject PRJNA1198918 and SRA study SRP550806. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 39841599) ↗
Study design
4 × pituitary gland, isotype control, biol vs 4 × pituitary gland, anti-CD115 depletion, biol

Supports a between-group comparison across 8 samples.

How we read this: 2 replicated groups read from 12 sample titles; they account for 8 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.

Samples in this study
Datasets on a similar topic

Search all mouse RNA-seq datasets in GEO →

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Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.