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Transcriptomic analysis of HepG2 cells overexpressing DNMT3A

GSE284401 Homo sapiens Expression profiling by high throughput sequencing 8 samples Submitted 2024/12/23 Platform GPL24676
Summary
Chronic hepatitis B virus (HBV) infection is the main etiology of liver fibrosis (LF), leading to cirrhosis and liver tumors. DNA methylation caused by HBV protein changes the liver microenvironment and activates hepatic stellate cells, which is an important mechanism of liver fibrosis. However, the exact mechanism remains unclear. DNA methyltransferase 3A (DNMT3A) is a major enzyme that promotes DNA methylation. HBV infection promotes the expression of DNMT3A. To determine the specific roles of DNMT3A, we used lentivirus to overexpress DNMT3A in hepatocellular carcinoma cell line (HepG2). And the changes of transcriptome were analysed by RNA-seq.
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Direct links to NCBI, no account and no request form: the whole study as GSE284401_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 8 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1198943 and SRA study SRP551777. Searching any of these in the dataset finder brings you back here.

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