lncSLERT promotes liver metastasis in colorectal cancer by down-regulating HUNK expression via RBM15-mediated m6A modification
RNA-seq (gene expression) · human · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Topic
- Colorectal cancerThis series is part of our curated briefing on it.
- Samples
- 12 samples: 3 × HCT116NC vs 3 × HCT116OE vs 3 × LoVoNC vs 3 × LoVoSHGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- lncSLERT Promotes Liver Metastasis in Colorectal Cancer by Down-Regulating HUNK Expression via RBM15-Mediated m6A ModificationOncoTargets and therapy · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE284657_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1200007 and SRA study SRP552493. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 4 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8689973 HCT116NC1 HCT116NC
- GSM8689974 HCT116NC2 HCT116NC
- GSM8689975 HCT116NC3 HCT116NC
- GSM8689976 HCT116OE1 HCT116OE
- GSM8689977 HCT116OE2 HCT116OE
- GSM8689978 HCT116OE3 HCT116OE
- GSM8689979 LoVoNC1 LoVoNC
- GSM8689980 LoVoNC2 LoVoNC
- GSM8689981 LoVoNC3 LoVoNC
- GSM8689982 LoVoSH1 LoVoSH
- GSM8689983 LoVoSH2 LoVoSH
- GSM8689984 LoVoSH3 LoVoSH
- GSE250000 Bulk RNA-sequencing of transduced colorectal cancer cell line HCT-116 and breast cancer cell line MCF-7 overexpressing full-lenght p53β or p53β-stop-lost. 4 samples same disease briefing · shares colorectal
- GSE12032 Inherent gene signature of stage II and III colorectal cancer leads in individual recurrence 198 samples same disease briefing · shares colorectal
- GSE109308 Single-cell transcriptomic survey of adenomatous polyposis patients with germline APC mutations 97 samples same disease briefing
- GSE110009 Single cell transcriptome landscape of primary and metastatic tumor in colon cancer 76 samples same disease briefing
- GSE124480 Gene expression of human colon cancer HCT116 cells 5 samples same disease briefing
- GSE244794 AS01-adjuvanted vaccine promotes functional and epigenetic modifications in monocytes [RNA-seq] 45 samples shares modification, promotes
- GSE244793 AS01-adjuvanted vaccine promotes functional and epigenetic modifications in monocytes [scRNA-seq] 31 samples shares modification, promotes
- GSE241147 IGF2BP3 promotes mRNA degradation through internal m7G modification [RNA-Seq] 24 samples shares modification, promotes
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.